Vidalista works by inhibiting the enzyme PDE5, which regulates blood flow in the penis. By blocking this enzyme, tadalafil allows the blood vessels in the penis to relax, leading to increased blood flow when sexually stimulated.Duration of Action: One of the standout features of Vidalista is its long-lasting effect. Unlike some other ED medications, Vidalista can remain effective for up to 36 hours, allowing greater flexibility in terms of when sexual activity can occur. This is why tadalafil is sometimes referred to as the “weekend pill.”